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Rabbit Anti-beta-Actin (Loading Control) antibody (bs-0061R)
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产品编号bs-0061R
英文名称beta-Actin (Loading Control)
中文名称β-肌动蛋白/β-Actin 抗体(内参抗体)
别    名Beta Actin; beta-Actin; ACTB; Actin cytoplasmic 1; Actin, beta; Beta actin; beta cytoskeletal actin;A X actin like protein; ACTB; Actin cytoplasmic 1; alpha sarcomeric Actin; Actx; Beta cytoskeletal actin; Melanoma X actin; PS1TP5BP1; ACTB_HUMAN.  
Specific References  (188)     |     bs-0061R has been referenced in 188 publications.
[IF=7.82] Han, Jianfeng, et al. "Cationic Bovine Serum Albumin Based Self‐Assembled Nanoparticles as siRNA Delivery Vector for Treating Lung Metastatic Cancer." Small 10.3 (2014): 524-535.  WB ;  Mouse.  
[IF=7.60] Teng, I., et al. "Phospholipid-functionalized mesoporous silica nanocarriers for selective photodynamic therapy of cancer." Biomaterials (2013).  WB ;  Mouse.  
[IF=7.60] Xiang, Bai, et al. "PSA-responsive and PSMA-mediated multifunctional liposomes for targeted therapy of prostate cancer." Biomaterials (2013).  WB ;  Human.  
[IF=6.34] Li, Xiaoxia, et al. "AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells." Arteriosclerosis, thrombosis, and vascular biology 28.10 (2008): 1789-1795.  WB ;  Human.  
[IF=5.21] Ma, Yanqin, et al. "Inflammatory responses induced by fluoride and arsenic at toxic concentration in rabbit aorta." Archives of toxicology 86.6 (2012): 849-856.  WB ;  Rabbit.  
[IF=4.41] Zeng, Xiaoyun, et al. "A Newly Synthesized Sinapic Acid Derivative Inhibits Endothelial Activation In Vitro and In Vivo." Molecular Pharmacology (2013).  WB ;  Human.  
[IF=4.26] Wang, Ye-Jun, et al. "Two oral HBx vaccines delivered by live attenuated< i> Salmonella: Both eliciting effective anti-tumor immunity." Cancer letters 263.1 (2008): 67-76.  WB ;  
[IF=4.13] Fu, Chenglai, et al. "Cholesterol increases adhesion of monocytes to endothelium by moving adhesion molecules out of caveolae." Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids 1801.7 (2010): 702-710.  WB ;  
[IF=3.84] Yin, Di, et al. "Functional graphene oxide as a plasmid-based Stat3 siRNA carrier inhibits mouse malignant melanoma growth in vivo." Nanotechnology 24.10 (2013): 105102.  WB ;  Mouse.  
[IF=3.84] Yin, Di, et al. "Functional graphene oxide as a plasmid-based Stat3 siRNA carrier inhibits mouse malignant melanoma growth in vivo." Nanotechnology 24.10 (2013): 105102.  WB ;  
[IF=3.73] Wang, Wei, et al. "Cynoglossus semilaevis ISG15: A Secreted Cytokine-Like Protein That Stimulates Antiviral Immune Response in a LRGG Motif-Dependent Manner." PLOS ONE 7.9 (2012): e44884.  WB ;  
[IF=3.73] Gao, Jin-Hang, et al. "Celecoxib Ameliorates Portal Hypertension of the Cirrhotic Rats through the Dual Inhibitory Effects on the Intrahepatic Fibrosis and Angiogenesis." PLOS ONE 8.7 (2013): e69309.  WB ;  Rat.  
[IF=3.73] Hou, Cong-Cong, and Wan-Xi Yang. "Acroframosome-Dependent KIFC1 Facilitates Acrosome Formation during Spermatogenesis in the Caridean Shrimp Exopalaemon modestus."?PLOS ONE?8.9 (2013): e76065.  WB ;  
[IF=3.64] Shi, Ran-ran, et al. "The immunogenicity of a novel cytotoxic T lymphocyte epitope from tumor antigen PL2L60 could be enhanced by 4-chlorophenylalanine substitution at position 1."?Cancer Immunology, Immunotherapy?(2013): 1-10.  WB ;  Human.  
[IF=3.55] Guo, Hong-Feng, et al. "Piezoelectric PU/PVDF electrospun scaffolds for wound healing applications." Colloids and Surfaces B: Biointerfaces (2012).  WB ;  Mouse.  
[IF=3.28] Li, Bing-Hua, et al. "Polypeptide from Chlamys farreri inhibits UVB-induced HaCaT cells apoptosis via inhibition CD95 pathway and reactive oxygen species." Free radical research 41.11 (2007): 1224-1232.  WB ;  Human.  
[IF=3.24] Chen, Cheng, et al. "The galectin-3-binding protein of< i> Cynoglossus semilaevis is a secreted protein of the innate immune system that binds a wide range of bacteria and is involved in host phagocytosis." Developmental & Comparative Immunology (2012).  WB, IP ;  
[IF=3.24] Qiu, Reng, et al. "Macrophage migration inhibitory factor of< i> Sciaenops ocellatus regulates immune cell trafficking and is involved in pathogen-induced immune response." Developmental & Comparative Immunology (2013).  WB ;  
[IF=3.24] Zhang, Jian, Ling Chen, and Li Sun. "SmLMWPTP, a teleost low molecular weight protein tyrosine phosphatase, inhibits the immune response of peripheral blood leukocytes in a manner that depends on the conserved P-loop." Developmental & Comparative Immunology (2013).  WB ;  
[IF=3.24] Li, Mo-fei, et al. "First characterization of a teleost Epstein-Barr virus-induced gene 3 (EBI3) reveals a regulatory effect of EBI3 on the innate immune response of peripheral blood leukocytes." Developmental & Comparative Immunology (2013).  WB ;  Rat.  
[IF=3.24] Chen, Cheng, et al. "The galectin-3-binding protein of< i> Cynoglossus semilaevis is a secreted protein of the innate immune system that binds a wide range of bacteria and is involved in host phagocytosis." Developmental & Comparative Immunology (2012).  WB ;  
[IF=3.15] Liu, Ping, et al. "Effects of pubertal fenvalerate exposure on testosterone and estradiol synthesis and the expression of androgen and estrogen receptors in the developing brain." Toxicology Letters 201.2 (2011): 181-189.  WB ;  Mouse.  
[IF=3.12] Ye, R., et al. "Ginsenoside Rd attenuates mitochondrial dysfunction and sequential apoptosis after transient focal ischemia." Neuroscience 178 (2011): 169-180.  WB ;  Rat.  
[IF=2.97] Liu, Donghui, et al. "Nonenzymatic glycation of high?density lipoprotein impairs its anti?inflammatory effects in innate immunity."iabetes/Metabolism Research and Reviews 28.2 (2012): 186-195..3  WB ;  Human.  
[IF=2.97] Sun, Yuan, et al. "Carbon disulfide exposure at peri-implantation disrupts embryo implantation by decreasing integrin ??< sub> 3 expression in the uterine tissue of pregnant mice."Chemico-biological interactions?(2013).x  WB ;  Mouse.  
[IF=2.96] Yu, Lan-ping, et al. "Characterization of a c-type lysozyme of Scophthalmus maximus: expression, activity, and antibacterial effect." Fish & Shellfish Immunology (2012).  WB ;  
[IF=2.91] Zhong, Zhiwei, et al. "miR-21 induces cell cycle at S phase and modulates cell proliferation by down-regulating hMSH2 in lung cancer." Journal of cancer research and clinical oncology 138.10 (2012): 1781-1788.  WB ;  Human.  
[IF=2.66] Ye, Ruidong, et al. "Ginsenoside Rd attenuates early oxidative damage and sequential inflammatory response after transient focal ischemia in rats." Neurochemistry international 58.3 (2011): 391-398.  WB ;  Rat.  
[IF=2.66] Han, Xiaohua, et al. "Antioxidant action of 7, 8-dihydroxyflavone protects PC12 cells against 6-hydroxydopamine-induced cytotoxicity." Neurochemistry International (2013).  WB ;  Rat.  
[IF=2.66] Feng, Ming, et al. "Ulinastatin Attenuates Experimental Autoimmune Encephalomyelitis by Enhancing Anti-inflammatory Responses." Neurochemistry international (2013).  WB ;  Mouse.  
[IF=2.52] Zhong, Zhiwei, et al. "MicroRNA-31-5p modulates cell cycle by targeting human mutL homolog 1 in human cancer cells." Tumor Biology (2013): 1-7.  WB ;  Human.  
[IF=2.41] He, Siyi, et al. "miR-138 protects cardiomyocytes from hypoxia-induced apoptosis via MLK3/JNK/c-jun pathway." Biochemical and biophysical research communications (2013).  WB ;  
[IF=2.33] Pan, Lin, et al. "Lin-28 reactivation is required for let-7 repression and proliferation in human small cell lung cancer cells." Molecular and cellular biochemistry 355.1-2 (2011): 257-263.  WB ;  Human.  
[IF=2.21] Deng, Xiao Li, et al. "Comparative study on circulating endothelial progenitor cells in systemic lupus erythematosus patients at active stage." Rheumatology international 30.11 (2010): 1429-1436.  WB ;  Human.  
[IF=2.15] Gao, Wei, et al. "Study of critical role of c-Met and its inhibitor SU11274 in colorectal carcinoma." Medical Oncology 30.2 (2013): 1-8.  WB ;  Human.  
[IF=2.14] Zhang, Zhan, et al. "Differential expression of beta-catenin and dickkopf-1 in the third trimester placentas from normal and preeclamptic pregnancies: a comparative study." Reproductive Biology and Endocrinology 11.1 (2013): 17.  WB ;  Human.  
[IF=2.12] Ruan Lin, et al. "Tetrandrine Attenuated Cerebral Ischemia/Reperfusion Injury and Induced Differential Proteomic Changes in a MCAO Mice Model Using 2-D DIGE." Neurochemical Research (2013). 1-9.  WB ;  Rat.  
[IF=2.09] Tao, Liu, et al. "In vitro study on human cytomegalovirus affecting early pregnancy villous EVT??s invasion function."Virology Journal 8.1 (2011): 1-8.D  WB ;  Human.  
[IF=2.05] Nie, Lihong, et al. "The anti-apoptotic effect of hydrogen sulfide attenuates injuries to the medullary respiratory centers of neonatal rats subjected to in utero cigarette smoke exposure." Respiratory physiology & neurobiology (2013).  WB ;  Rat.  
[IF=1.77] Chen, Cui-Ying, et al. "Characterization of cytotoxicity-related gene expression in response to virulent Marek??s disease virus infection in the bursa of Fabricius."Research in veterinary science (2012).q  WB ;  Chicken.  
[IF=1.74] Wang, Peng, et al. "Recombinant adenovirus expressing ICP47 gene suppresses the ability of dendritic cells by restricting specific T cell responses." Cellular Immunology (2013).  WB ;  Human.  
[IF=1.69] GAO, DAN, et al. "Effect of peritoneal dialysis on expression of vascular endothelial growth factor, basic fibroblast growth factor and endostatin of the peritoneum in peritoneal dialysis patients." Nephrology 16.8 (2011): 736-742.  WB ;  Human.  
[IF=1.31] Wang, Chunqiang, Wei Ma, and Yuhong Su. "NF-??B Pathway Contributes to Cadmium-Induced Apoptosis of Porcine Granulosa Cells."Biological trace element research (2013): 1-8.c  WB ;  Pig.  
[IF=1.25] Zhao, Yu, and Shijun Wang. "Neural Stem Cell Transplantation Inhibits Apoptosis through Activation of MAPK/ERK Signaling Pathway in Cerebral Ischemia/Reperfusion Rats." International Journal of Clinical and Experimental Neurology 1.1 (2013): 5-11.  WB ;  Rat.  
[IF=1.10] Zhou, Jing, et al. "Effects of low-dose hydroxychloroquine on expression of phosphorylated Akt and p53 proteins and cardiomyocyte apoptosis in peri-infarct myocardium in rats."?Experimental & Clinical Cardiology?18.2 (2013): e95.  WB ;  Rat.  
[IF=0.90] Zhang, Xiao-ling, et al. "Vascular endothelial growth factor up-regulates the expression of intracellular adhesion molecule-1 in retinal endothelial cells via reactive oxygen species, but not nitric oxide." Chinese Medical Journal (English Edition) 122.3 (2009): 338.  WB ;  Bovine.  
[IF=0.34] Wang, Gui-Jun, et al. "Expression of tissue factor pathway inhibitor-2 in gastric stromal tumor and its clinical significance." Experimental and Therapeutic Medicine.  WB ;  Human.  
[IF=3.42] Xu, R., et al. "Secretoneurin Induces Airway Mucus Hypersecretion by Enhancing the Binding of EGF to NRP1." Cellular Physiology and Biochemistry 33.2 (2014): 446-456.  WB ;  Human.  
[IF=1.73] Zeng, Q. J., et al. "Decorin-induced proliferation of avian myoblasts involves the myostatin/Smad signaling pathway." Poultry Science 93.1 (2014): 138-146.  WB ;  
[IF=5.13] Liu, Qun, et al. "6-Shogaol induces apoptosis in human leukemia cells through a process involving caspase-mediated cleavage of eIF2α." Molecular cancer 12.1 (2013): 135.  WB ;  Human.  
[IF=2.35] Mao, Nan, et al. "Ginsenoside Rg1 protects mouse podocytes from aldosterone-induced injury in vitro." Acta Pharmacologica Sinica (2014).  WB ;  Mouse.  
[IF=2.69] Lin, Caiyu, et al. "Lithocarpus Polystachyus Rehd Leaf Aqueous Extract Inhibits Human Breast Cancer Growth In Vitro and In Vivo." Nutrition and Cancer (2014).  WB ;  Human.  
[IF=3.17] Liu, Yang, et al. "Amelioration of Stroke-Induced Neurological Deficiency by Lyophilized Powder of Catapol and Puerarin." International Journal of Biological Sciences 10.4 (2014): 448-456.  WB ;  Mouse.  
[IF=3.79] Wang, Xiaoqiu, et al. "Temporal Proteomic Analysis Reveals Defects in Small Intestinal Development of Porcine Fetuses with Intrauterine Growth Restriction." The Journal of Nutritional Biochemistry (2014).  WB ;  
[IF=2.33] Tao, Hong, et al. "Histone methyltransferase G9a and H3K9 dimethylation inhibit the self-renewal of glioma cancer stem cells." Molecular and Cellular Biochemistry (2014): 1-8.  WB ;  Human.  
[IF=5.07] Song, Dongmei, et al. "Ulinastatin Activates Heme Oxygenase‐1 Antioxidant Pathway and Attenuates Allergic Inflammation." British Journal of Pharmacology (2014).  WB ;  Mouse.  
[IF=1.09] Zhao, Zhilong, et al. "Expression of natriuretic peptide receptor-A in esophageal squamous cell carcinomas and the relationship with tumor invasion and migration." World Journal of Surgical Oncology 12.1 (2014): 154.  WB ;  Human.  
[IF=2.35] Xu, Jiao-jiao, et al. "Dopamine D1 receptor activation induces dehydroepiandrosterone sulfotransferase (SULT2A1) in HepG2 cells." Acta Pharmacologica Sinica (2014).  WB ;  Human.  
[IF=1.14] Wang, J., et al. "Esculetin, a coumarin derivative, exerts in vitro and in vivo antiproliferative activity against hepatocellular carcinoma by initiating a mitochondrial-dependent apoptosis pathway." Brazilian Journal of Medical and Biological Research (2014): 000-000.  WB ;  Mouse.  
[IF=2.43] Li, Ping, et al. "CNP signal pathway up-regulated in rectum of depressed rats and the interventional effect of Xiaoyaosan." World Journal of Gastroenterology: WJG 21.5 (2015): 1518.  WB ;  Rat.  
[IF=1.61] Jiang, Yun-Yun, et al. "Characterization and Expression of Chicken Selenoprotein U." Biological Trace Element Research (2015): 1-9.  WB ;  
[IF=2.50] Ji, Xi-wei, et al. "Intratumoral estrogen sulfotransferase induction contributes to the anti-breast cancer effects of the dithiocarbamate derivative TM208." Acta Pharmacologica Sinica (2015).  WB ;  Human.  
[IF=2.38] Li, Gang, et al. "Ectopic WWOX Expression Inhibits Growth of 5637 Bladder Cancer Cell In Vitro and In Vivo." Cell Biochemistry and Biophysics: 1-9.  WB ;  Mouse.  
[IF=3.79] Fu, Yujie, et al. "Activity of the anti-estrogenic cajanin stilbene acid towards breast cancer." The Journal of Nutritional Biochemistry (2015).  WB ;  Human.  
[IF=2.56] Wang, P. et al. "Attenuation of cytokine production of interleukine -2 and perforin in Two-way mixed lymphocyte reaction by highly efficient transduction of the recombinant adenovirus expressing ICP47 gene." Life Sci J 2013;10(3):963-969  WB ;  
[IF=1.89] Zong, Shaohui, et al. "Effects of Polygonatum sibiricum polysaccharide on the osteogenic differentiation of bone mesenchymal stem cells in mice." International Journal of Clinical and Experimental Pathology8.6 (2015): 6169-6180.  WB ;  Mouse.  
[IF=1.55] Hou, Yan, et al. "miR‑215 functions as a tumor suppressor and directly targets ZEB2 in human non‑small cell lung cancer." Oncology Letters.  WB ;  Human.  
[IF=3.53] Wang, Bingxiang, et al. "7, 8-Dihydroxyflavone Protects an Endothelial Cell Line from H 2 O 2 Damage." PloS one 10.8 (2015): e0135345.  WB ;  Human.  
[IF=1.55] Chang, Liang, et al. "Activation of sonic hedgehog signaling enhances cell migration and invasion by induction of matrix metalloproteinase-2 and-9 via the phosphoinositide-3 kinase/AKT signaling pathway in glioblastoma." Molecular Medicine Reports. (2015).  WB ;  
[IF=4.50] Jiao, Zhang Jiao, et al. "MicroRNA-1285 regulates 17β-estradiol-inhibited immature boar Sertoli cell proliferation via adenosine monophosphate-activated protein kinase activation." Endocrinology (2015): en-2014.  WB ;  
[IF=3.68] He, Mu-Dan, et al. "Efficient ligase 3-dependent microhomology-mediated end joining repair of DNA double-strand breaks in zebrafish embryos." Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis (2015).  WB ;  
[IF=1.55] Qi, Zhonghua, et al. "Naringin ameliorates cognitive deficits via oxidative stress, proinflammatory factors and the PPARγ signaling pathway in a type 2 diabetic rat model." Molecular Medicine Reports.  WB ;  
[IF=5.14] Xu, Xiaofeng, et al. "Preferential Heme Oxygenase-1 Activation in Striatal Astrocytes Antagonizes Dopaminergic Neuron Degeneration in MPTP-Intoxicated Mice." Molecular Neurobiology (2015): 1-10.  WB ;  Mouse.  
[IF=6.41] Long, Yan-Min, et al. "Negatively charged silver nanoparticles cause retinal vascular permeability by activating plasma contact system and disrupting adherens junction." Nanotoxicology (2015): 1-11.  WB ;  
[IF=2.53] Yang, Zhang, et al. "Protective effects of mangiferin on cerebral ischemia–reperfusion injury and its mechanisms." European Journal of Pharmacology (2016).  WB ;  Rat.  
[IF=2.72] Wan, Dan, et al. "Resveratrol Provides Neuroprotection by Inhibiting Phosphodiesterases and Regulating the cAMP/AMPK/SIRT1 Pathway after Stroke in Rats." Brain Research Bulletin (2016).  WB ;  Rat.  
[IF=2.70] Abdelzaher, Lobna A., et al. "Astaxanthin alleviates oxidative stress insults-related derangements in human vascular endothelial cells exposed to glucose fluctuations." Life Sciences (2016).  WB ;  Human.  
[IF=1.28] Wu, Xue-Mei, et al. "Inhibition of connexin 36 decreases seizure activity in the Kainic acid-induced rat model of epilepsy." Int J Clin Exp Med 9.2 (2016): 2277-2284.  WB ;  Rat.  
[IF=2.53] Yoshinaga, Ayana, et al. "NEU3 inhibitory effect of naringin suppresses cancer cell growth by attenuation of EGFR signaling through GM3 ganglioside accumulation." European Journal of Pharmacology (2016).  WB ;  Human.  
[IF=0.73] Asada, Dai, Toshiyuki Itoi, and Kenji Hamaoka. "The tolerance to ischemia reperfusion injury in a congenital heart disease model." Pediatrics International (2016)  WB ;  Rat.  
[IF=0.00] Sondag, Gregory R. OSTEOACTIVIN AND CD44: A NOVEL INTERACTION REGULATING BONE CELL DIFFERENTIATION AND FUNCTION. Diss. Kent State University, 2015.  WB ;  Mouse.  
[IF=3.84] Chen, Siying, et al. "HDACI regulates the PI3K/Akt signaling pathway to reverse MCF-7/PTX resistance by inhibiting SET." RSC Advances (2016).  WB ;  Human.  
[IF=3.81] Huang, Yu‐lin, et al. "Spermatogenesis‐associated proteins at different developmental stages of buffalo testicular seminiferous tubules identified by comparative proteomic analysis." Proteomics (2016).  WB ;  Other Species.  
[IF=1.74] Li, Hui, et al. "The Role of ΔFosB on the Pro-survival Effect of PTHrP in Goat Mammary Epithelial Cells." Applied Biochemistry and Biotechnology(2016): 1-10.  WB ;  Goat.  
[IF=2.90] Zhang, Jianhai, et al. "Sodium fluoride and sulfur dioxide affected male reproduction by disturbing blood-testis barrier in mice." Food and Chemical Toxicology (2016).  WB ;  Mouse.  
[IF=5.58] Cai, Xingcai, et al. "Alpha-ketoglutarate promotes skeletal muscle hypertrophy and protein synthesis through Akt/mTOR signaling pathways."Scientific Reports 6 (2016): 26802.  WB ;  Mouse.  
[IF=2.66] Lin, Qin-Qin, et al. "SIRT1 regulates TNF-α-induced expression of CD40 in 3T3-L1 adipocytes via NF-κB pathway." Cytokine 60.2 (2012): 447-455.  WB ;  
[IF=5.41] Yan, Wenjun, et al. "SirT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain." Journal of Cerebral Blood Flow & Metabolism 33.3 (2013): 396-406.  Rat.  
[IF=0.63] Mu, Yang, et al. "Up-regulation of phosphorylated ATM/ATR substrate/Akt expression by phenylephrine in peri-infarct myocardium in rats." Acta Cardiol Sin 27.3 (2011): 182-8.  WB ;  Rat.  
[IF=1.93] Xiong, Zhang, et al. "Curcumin mediates presenilin-1 activity to reduce β-amyloid production in a model of Alzheimer’s Disease." Pharmacological Reports 63.5 (2011): 1101-1108.  WB ;  Human.  
[IF=0.60] Yin, Zhihong, et al. "Identification of differentially expressed Gnαs and Gnα11 in sheep (Ovis aries) skins associated with white and black coat colors." Acta histochemica (2016).  WB ;  Sheep.  
[IF=3.40] Ruan Z, Liu S, Zhou Y, Mi S, Liu G, Wu X, et al. (2014) Chlorogenic Acid Decreases Intestinal Permeability and Increases Expression of Intestinal Tight Junction Proteins in Weaned Rats Challenged with LPS. PLoS ONE 9(6): e97815  WB ;  Rat.  
[IF=0.84] Liu, Xiao-Lan, et al. "Increased expression of Dock180 protein in the noninfarcted myocardium in rats." Journal of the Chinese Medical Association 76.3 (2013): 164-168.  WB ;  Rat.  
[IF=1.70] Yan, An, et al. "Pro-survival effect of Dock180 overexpression on rat-derived H9C2 cardiomyocytes." Medical science monitor basic research 19 (2013): 12-19.  WB ;  Rat.  
[IF=4.38] Zhu, Yuxuan, et al. "Antioxidant and Antiapoptotic Effects of 1, 1′-(Biphenyl-4, 4′-diyl)-bis (3-(dimethylamino)-propan-1-one) on Protecting PC12 Cells from Aβ-Induced Injury." Molecular pharmaceutics 11.2 (2013): 428-435.  WB ;  Rat.  
[IF=3.26] Chen, Chuanxiang, et al. "Role of PUMA in methamphetamine-induced neuronal apoptosis." Toxicology letters 240.1 (2016): 149-160.  WB ;  Rat.  
[IF=1.55] Chang, Liang, et al. "Activation of sonic hedgehog signaling enhances cell migration and invasion by induction of matrix metalloproteinase-2 and-9 via the phosphoinositide-3 kinase/AKT signaling pathway in glioblastoma. Corrigendum in/mmr/12/5/7815." Molecular medicine reports 12.5 (2015): 6702-6710.  WB ;  Human.  
[IF=2.98] Zhang, Heng, et al. "Pubertal and early adult exposure to fenvalerate disrupts steroidogenesis and spermatogenesis in mice at adulthood." Journal of Applied Toxicology 30.4 (2010): 369-377.  WB ;  
[IF=4.57] Tsuboi, Koichiro, et al. "Autophagy protects against colitis by the maintenance of normal gut microflora and secretion of mucus." Journal of Biological Chemistry 290.33 (2015): 20511-20526.  WB ;  Mouse.  
[IF=1.55] Cheng, Yunpeng, et al. "Effect of oxidized low-density lipoprotein on the expression of the prorenin receptor in human aortic smooth muscle cells."Molecular medicine reports 11.6 (2015): 4341-4344.  WB ;  Human.  
[IF=3.23] Lin, Xue-Lian, et al. "NPs/NPRs Signaling Pathways May Be Involved in Depression-Induced Loss of Gastric ICC by Decreasing the Production of mSCF." PloS one 11.2 (2016): e0149031.  WB ;  Rat.  
[IF=2.70] Kou, Shuming, et al. "Synergetic cholesterol-lowering effects of main alkaloids from Rhizoma Coptidis in HepG2 cells and hypercholesterolemia hamsters." Life Sciences (2016).  WB ;  Human.  
[IF=5.14] Xu, Xiaofeng, et al. "Prevention of Hippocampal Neuronal Damage and Cognitive Function Deficits in Vascular Dementia by Dextromethorphan."Molecular Neurobiology (2016): 1-9.  WB ;  
[IF=2.51] Ji-wei, Hu, et al. "Effects of Mfn2 Gene Overexpression on EGFR Expression and Angiogenesis of a Heterologous Graft Model for Human Breast Infiltrating Duct Carcinoma in Nude Mice." American Journal of Cancer Prevention 3.6 (2015): 117-121.  WB ;  Mouse.  
[IF=3.38] Sun, Cheng, et al. "Silver nanoparticles induced neurotoxicity through oxidative stress in rat cerebral astrocytes is distinct from the effects of silver ions." NeuroToxicology (2015).  WB ;  
[IF=3.61] Wang, Li, et al. "Silencing stem cell factor attenuates stemness and inhibits migration of cancer stem cells derived from Lewis lung carcinoma cells."Tumor Biology (2015): 1-15.  WB ;  Mouse.  
[IF=3.70] Wu, Yuting, et al. "Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion."Toxicology and Applied Pharmacology (2015).  WB ;  Mouse.  
[IF=3.02] Wang, Yao, et al. "Autophagy induced by snakehead fish vesiculovirus inhibited its replication in SSN-1 cell line." Fish & Shellfish Immunology(2016).  WB ;  Others.  
[IF=5.58]  Zhou, Xiaoqiao, et al. "Cecropin B Represses CYP3A29 Expression through Activation of the TLR2/4-NF-κB/PXR Signaling Pathway." Scientific Reports6 (2016): 27876.  WB ;  Pig.  
[IF=1.87] Xin, Ruijuan, et al. "MicroRNA-214 promotes peritoneal metastasis through regulating PTEN negatively in gastric cancer." Clinics and Research in Hepatology and Gastroenterology (2016).  WB ;  Human.  
[IF=0.78] Ma, X., et al. "Molecular cloning and expression vector construction of bovine TRIM28 Genet. Mol. Res. 15 (2)." Genet. Mol. Res 15: 2.  WB ;  Bovine.  
[IF=1.80] Zhao, Yangfei, et al. "Effect of Choline on the Composition and Degradation Enzyme of Extracellular Matrix of Mice Chondrocytes Exposed to Fluoride."Biological Trace Element Research (2016): 1-7.  WB ;  Mouse.  
[IF=4.22] Hou, Yiling, et al. "Structure elucidation, proliferation effect on macrophage and its mechanism of a new heteropolysaccharide from Lactarius deliciosus Gray." Carbohydrate Polymers (2016).  WB ;  Other Species.  
[IF=1.64] Fan, Wen-Jie, et al. "NF-κB is involved in the LPS-mediated proliferation and apoptosis of MAC-T epithelial cells as part of the subacute ruminal acidosis response in cows." Biotechnology Letters: 1-11.  WB ;  Bovine.  
[IF=0.13] Zhang, Z. J., et al. "Prospective experimental studies on the renal protective effect of ulinastatin after paraquat poisoning." World J Emerg Med 3.4 (2012): 299-304.  WB ;  Rat.  
[IF=1.72] Liang, Guojuan, et al. "The protective effect of caffeic acid on global cerebral ischemia-reperfusion injury in rats." Behavioral and Brain Functions 11.1 (2015): 1.  WB ;  Rat.  
[IF=2.30] Mo, Xian-Gang, et al. "Suppression of NHE1 by small interfering RNA inhibits HIF-1α-induced angiogenesis in vitro via modulation of calpain activity." Microvascular research 81.2 (2011): 160-168.  All.  
[IF=1.38] Huang, Chen, et al. "Expression, purification, and functional characterization of recombinant PTD-SARA." Acta biochimica et biophysica Sinica 43.2 (2011): 110-117.  WB ;  
[IF=2.62] Li, Zhifu, et al. "Celecoxib Combined with Diacerein Effectively Alleviates Osteoarthritis in Rats via Regulating JNK and p38MAPK Signaling Pathways." Inflammation 38.4 (2015): 1563-1572.  WB ;  Rat.  
[IF=11.48] Lan, Feng, et al. "Forkhead box protein 3 in human nasal polyp regulatory T cells is regulated by the protein suppressor of cytokine signaling 3." Journal of Allergy and Clinical Immunology 132.6 (2013): 1314-1321.  WB ;  Human.  
[IF=3.18] Yang, Ya’nan, et al. "Vitellogenin2: spermatozoon specificity and immunoprotection in mud crabs." Reproduction 152.3 (2016): 235-243.  ELISA ;  Other Species.  
[IF=2.37] Huang, Huibin, et al. "Upregulation of TSHR, TTF-1, and PAX8 in Nodular Goiter Is Associated with Iodine Deficiency in the Follicular Lumen."International Journal of Endocrinology 2016 (2016).  WB ;  Human.  
[IF=2.81] Yan, Xiaoting, et al. "Decreased expression of the vitamin D receptor in women with recurrent pregnancy loss." Archives of Biochemistry and Biophysics (2016).  WB ;  
[IF=2.61] Li, Yuan-bo, et al. "Methotrexate affects HMGB1 expression in rheumatoid arthritis, and the downregulation of HMGB1 prevents rheumatoid arthritis progression." Molecular and Cellular Biochemistry: 1-10.  Human.  
[IF=2.17] Xiong, Xiaoqin, et al. "Comparative Developmental Toxicity and Stress Protein Responses of Dimethyl Sulfoxide to Rare Minnow and Zebrafish Embryos/Larvae." Zebrafish (2016).  WB ;  Others.  
[IF=0.90] Suzuki, Tomoyuki, et al. "Atrial natriuretic peptide induces peroxisome proliferator activated receptor γ during cardiac ischemia–reperfusion in swine heart." General Thoracic and Cardiovascular Surgery (2016): 1-11.  WB ;  Pig.  
[IF=2.93] Wang, Yun-Yan, et al. "LINC00312 inhibits the migration and invasion of bladder cancer cells by targeting miR-197-3p." Tumor Biology (2016): 1-11.  WB ;  Human.  
[IF=1.58] Lu, Wei, et al. "MicroRNA-421 enhances cell migration and invasion by down-regulating TIMP-2 in glioblastoma." Int J Clin Exp Med 9.8 (2016): 15876-15883.  WB ;  Human.  
[IF=2.55] Gao, Xinran, et al. "LOX-1 and TLR4 affect each other and regulate the generation of ROS in A. fumigatus keratitis." International Immunopharmacology 40 (2016): 392-399.  WB ;  Mouse.  
[IF=3.14] Yang, Zhaoting, et al. "Gli1, a potential regulator of esophageal cancer stem cell, is identified as an independent adverse prognostic factor in esophageal squamous cell carcinoma." Journal of Cancer Research and Clinical Oncology (2016): 1-12.  WB ;  Human.  
[IF=1.92] Liu, Chen, et al. "Pulmonary artery denervation improves pulmonary arterial hypertension induced right ventricular dysfunction by modulating the local renin-angiotensin-aldosterone system." BMC Cardiovascular Disorders 16.1 (2016): 192.  WB ;  Dog.  
[IF=5.23] Zhuang, Pengwei, et al. "cAMP-PKA-CaMKII signaling pathway is involved in aggravated cardiotoxicity during Fuzi and Beimu Combination Treatment of Experimental Pulmonary Hypertension." Scientific Reports 6 (2016): 34903.  WB ;  Rat.  
[IF=0.00] Xu, Jing, et al. "Construction of Conveniently Screening pLKO. 1-TRC Vector Tagged with TurboGFP." Applied Biochemistry and Biotechnology(2016): 1-11.  WB ;  Human.  
[IF=3.70] Ma, Yanqin, et al. "Arsenic and fluoride induce apoptosis, inflammation and oxidative stress in cultured human umbilical vein endothelial cells." Chemosphere 167 (2017): 454-461.  WB ;  Human.  
[IF=1.84] Zhao, Yong, et al. "Inhibition of peripubertal sheep mammary gland development by cysteamine through reducing progesterone and growth factor production." Theriogenology (2016).  WB ;  Sheep.  
[IF=1.48] Yan, Weihong, et al. "The effect of miR-146a on STAT1 expression and apoptosis in acute lymphoblastic leukemia Jurkat cells." Oncology Letters.  WB ;  Human.  
[IF=2.13] Zhang, Xiangying, Shuping Song, and Huixin Luo. "Regulation of podocyte lesions in diabetic nephropathy via miR-34a in the Notch signaling pathway." Medicine 95.44 (2016): e5050.  WB ;  Mouse.  
[IF=3.85] Wu, Yuting, et al. "Methylation of Septin9 mediated by DNMT3a enhances hepatic stellate cells activation and liver fibrogenesis." Toxicology and Applied Pharmacology 315 (2017): 35-49.  WB ;  Mouse.  
[IF=3.42] Li, Mei, et al. "Evaluation of the osteo-inductive potential of hollow three-dimensional magnesium-strontium substitutes for the bone grafting application." Materials Science and Engineering: C (2016).  WB ;  Mouse.  
[IF=2.86] Meng, Yingying, et al. "Lauric acid stimulates mammary gland development of pubertal mice through activation of GPR84 and PI3K/Akt signaling pathway." Journal of Agricultural and Food Chemistry (2016).  WB ;  Mouse.  
[IF=3.84] Shen, P. P., et al. "Cortical Spreading Depression (CSD) Preconditioning Mediates Neuroprotection against Ischemic Stroke by Inducing AMP‐activated Protein Kinase‐dependent Autophagy in a Rat Cerebral Ischemic/reperfusion Injury Model." Journal of Neurochemistry (2016).  WB ;  Rat.  
[IF=1.56] Xiang, Yan, et al. "Effect of Yi Guan Jian decoction on differentiation of bone marrow mesenchymalstem cells into hepatocyte-like cells in dimethylnitrosamine-induced liver cirrhosis in mice." Molecular Medicine Reports.  WB ;  Mouse.  
[IF=2.55] Wu, Xiaojuan, et al. "Purinergic P2X7 receptor mediates acetaldehyde-induced hepatic stellate cells activation via PKC-dependent GSK3β pathway." International Immunopharmacology 43 (2017): 164-171.  WB ;  Rat.  
[IF=2.55] Dinesh, Palani, and MahaboobKhan Rasool. "Berberine, an isoquinoline alkaloid suppresses TXNIP mediated NLRP3 inflammasome activation in MSU crystal stimulated RAW 264.7 macrophages through the upregulation of Nrf2 transcription factor and alleviates MSU crystal induced inflammation in rats." International Immunopharmacology 44 (2017): 26-37.  WB ;  Mouse.  
[IF=1.07] Liu, Cui-Zhen, et al. "HBSP attenuates lipopolysaccharide-induced inflammatory response in human renal proximal tubular epithelial cells by induction of Nrf2 via PI3K/Akt pathway." Int J Clin Exp Med 10.1 (2017): 587-597.  WB ;  Human.  
[IF=3.88] Ogura, Kohei, et al. "Vibrio cholerae Cholix toxin-induced HepG2 cell death is enhanced by tumor necrosis factor-alpha through ROS and intracellular signal-regulated kinases." Toxicological Sciences (2017): kfx009.  WB ;  Mouse.  
[IF=1.84] Shi, Lei, et al. "Effects of selenium on the proliferation, apoptosis and testosterone production of sheep Leydig cells in vitro." Theriogenology (2017).  WB ;  Sheep.  
[IF=3.02] Ryuzono, Sena, et al. "Suppression of Neu1 sialidase delays the absorption of yolk sac in medaka (Oryzias latipes) accompanied with the accumulation of α2-3 sialo-glycoproteins." Biochimie (2017).  WB ;  Other Species.  
[IF=3.85] Li, Yue, et al. "Autophagy contributes to 4-Amino-2-Trifluoromethyl-Phenyl Retinate-induced differentiation in human acute promyelocytic leukemia NB4 cells." Toxicology and Applied Pharmacology. (2017).  Human.  
[IF=6.36] Yoshino, Hirofumi, et al. "microRNA-210-3p depletion by CRISPR/Cas9 promoted tumorigenesis through revival of TWIST1 in renal cell carcinoma." Oncotarget.   WB ;  Human.  
[IF=3.39] Li, Yanhui, et al. "Role of the Lateral Habenula in Pain-Associated Depression." Frontiers in Behavioral Neuroscience 11 (2017): 31.  WB ;  Rat.  
[IF=1.84] Yao, Xiaolei, et al. "Characterization of GALNTL5 gene sequence and expression in ovine testes and sperm." Theriogenology (2017).  WB ;  Sheep.  
[IF=2.25] Xiong, Zhang, et al. "Curcumin mediates presenilin-1 activity to reduce β-amyloid production in a model of Alzheimer’s disease." Pharmacological Reports 63.5 (2011): 1101-1108.  WB ;  Human.  
[IF=1.56] Du, Jinghua, et al. "TLR4‑dependent signaling pathway modulation: A novel mechanism by which pioglitazone protects against nutritional fibrotic steatohepatitis in mice." Molecular medicine reports 13.3 (2016): 2159-2166.  WB ;  Mouse.  
[IF=2.94] Wang, Yanqin, et al. "Neuroprotective Effect and Mechanism of Thiazolidinedione on Dopaminergic Neurons In Vivo and In Vitro in Parkinson’s Disease." PPAR Research 2017 (2017).  WB ;  Mouse.  
[IF=2.19] Zhang, Jin-ming, et al. "Nrf2 Is Crucial For The Down-Regulation Of Cyp7a1 Induced By Arachidonic Acid In Hepg2 Cells." Environmental Toxicology and Pharmacology (2017).  WB ;  Human.  
[IF=1.83] Li, Gongchu, et al. "Ulva pertusa lectin 1 delivery through adenovirus vector affects multiple signaling pathways in cancer cells." Glycoconjugate Journal (2017): 1-10.  WB ;  Human.  
[IF=2.33] Ma, Zhihong, et al. "Paeoniflorin suppresses lipid accumulation and alleviates insulin resistance by regulating the Rho kinase/IRS-1 pathway in palmitate-induced HepG2Cells." Biomedicine & Pharmacotherapy 90 (2017): 361-367.  WB ;  Human.  
[IF=11.33] Leclercq, Sophie, et al. "Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior." Nature Communications 8 (2017): 15062.  WB ;  Mouse.  
[IF=3.62] Wang, Peng, et al. "Trans-generational enhancement of C-type lysozyme level in eggs of zebrafish by dietary β-glucan." Developmental & Comparative Immunology (2017).  other ;  
[IF=1.28] Li, Yunlun, et al. "Mechanism of the protective effects of the combined treatment with rhynchophylla total alkaloids and sinapine thiocyanate against a prothrombotic state caused by vascular endothelial cell inflammatory damage." Experimental and Therapeutic Medicine.  WB ;  Mouse.  
[IF=1.55] Zhang, Zhongti, et al. "Jak3 is involved in CCR7-dependent migration and invasion in metastatic squamous cell carcinoma of the head and neck." Oncology Letters 13.5 (2017): 3191-3197.  WB ;  Human.  
[IF=2.61] Yang, Yang, et al. "The epigenetically-regulated miR-34a targeting c-SRC suppresses RAF/MEK/ERK signaling pathway in K-562 cells." Leukemia Research 55 (2017): 91-96.  WB ;  Human.  
[IF=1.66] Xu, Dan-dan, et al. "17β-Estradiol and progesterone decrease MDP induced NOD2 expression in bovine mammary epithelial cells." Veterinary Immunology and Immunopathology (2017).  WB ;  Bovine.  
[IF=2.58] Huang, Xu, et al. "ICAM-1-Targeted Liposomes Loaded with Liver X Receptor Agonists Suppress PDGF-Induced Proliferation of Vascular Smooth Muscle Cells." Nanoscale Research Letters 12.1 (2017): 322.  WB ;  Mouse.  
[IF=3.85] Huang, Huimin, et al. "HMGA2, a driver of inflammation, is associated with hypermethylation in acute liver injury." Toxicology and Applied Pharmacology (2017).  WB ;  Mouse.  
[IF=3.14] Liu, Yaowen, Shuyao Wang, and Rong Zhang. "Composite poly (lactic acid)/chitosan nanofibrous scaffolds for cardiac tissue engineering." International Journal of Biological Macromolecules (2017).  WB ;  Rat.  
[IF=3.14] Varghese, Sheeja, et al. "The inhibitory effect of anti-tumor polysaccharide from Punica granatum on metastasis." International Journal of Biological Macromolecules (2017).  WB ;  Human.  
[IF=5.57] Sakaguchi, Takashi, et al. "Regulation of ITGA3 by the dual-stranded microRNA-199 family as a potential prognostic marker in bladder cancer." British journal of cancer 116.8 (2017): 1077.  WB ;  Human.  
[IF=1.22] Ma, Lili, et al. "Mori cortex prevents kidney damage through inhibiting expression of inflammatory factors in the glomerulus in streptozocin-induced diabetic rats." Iranian Journal of Basic Medical Sciences 20.6 (2017): 715-721.  WB ;  Rat.  
[IF=2.37] Wang, Mengyuan, et al. "miR-141-3p functions as a tumor suppressor modulating activating transcription factor 5 in glioma." Biochemical and Biophysical Research Communications (2017).  WB ;  Human.  
[IF=3.98] Lu, Naisheng, et al. "Butyric acid regulates progesterone and estradiol secretion via cAMP signaling pathway in porcine granulosa cells." The Journal of Steroid Biochemistry and Molecular Biology (2017).  WB ;  Pig.  
[IF=2.05] He, Siyi, et al. "Protective role of downregulated MLK3 in myocardial adaptation to chronic hypoxia." Journal of Physiology and Biochemistry (2017): 1-10.  WB ;  Human.  
[IF=5.48] Wu, Bin, et al. "Succinate-induced neuronal mitochondrial fission and hexokinase II malfunction in ischemic stroke: Therapeutical effects of kaempferol." Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease (2017).  WB ;  Mouse.  
[IF=2.16] Wang, Yi Ya, et al. "Epigenetic control of cyp19a1a expression is critical for high temperature induced Nile tilapia masculinization." Journal of Thermal Biology (2017).  WB ;  Other Species.  
[IF=1.75] Vinothkumar, G., et al. "Abnormal Amyloid β 42 expression and increased oxidative stress in plasma of CKD patients with cognitive dysfunction: A small scale case control study comparison with Alzheimer's disease." BBA Clinical (2017).  WB ;  Human.  
[IF=3.15] Yang, Kelin, et al. "Phytol promotes the formation of slow-twitch muscle fibers through PGC-1αmiRNA but not mitochondria oxidation." Journal of Agricultural and Food Chemistry (2017).  WB ;  Pig.  
[IF=2.82] Gao, Ling, et al. "Morusin shows potent antitumor activity for human hepatocellular carcinoma in vitro and in vivo through apoptosis induction and angiogenesis inhibition." Drug Design, Development and Therapy 11 (2017): 1789.  WB ;  Human.  
[IF=2.47] Meng, Yingying, et al. "Stearic acid suppresses mammary gland development by inhibiting PI3K/Akt signaling pathway through GPR120 in pubertal mice." Biochemical and Biophysical Research Communications (2017).  WB ;  Mouse.  
[IF=2.15] Xu, Xilin, et al. "Danshen attenuates osteoarthritis-related cartilage degeneration through inhibition of NF-κB signaling pathway in vivo and in vitro." Biochemistry and Cell Biology (2017).  WB ;  Rabbit.  
[IF=3.87] Hou, Yiling, et al. "Structure elucidation and antitumor activity of a new polysaccharide from Maerkang Tricholoma matsutake." International Journal of Biological Sciences 13.7 (2017): 935-948.  WB ;  Mouse.  
[IF=4.26] Li, Chengcheng, et al. "Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-κB signaling pathway." Scientific Reports 7 (2017).  WB ;  Mouse.  
[IF=0.57] Shi, Hua-Li, et al. "Effect of polygonimitin C on bone formation and resorption in human osteoblast-like MG63 cells." Tropical Journal of Pharmaceutical Research 16.7 (2017): 1595-1600.  WB ;  Human.  
[IF=1.99] Yao, Xiaolei, et al. "Vitamin D receptor expression and potential role of vitamin D on cell proliferation and steroidogenesis in goat ovarian granulosa cells." Theriogenology (2017).  WB ;  Goat.  
[IF=1.42] Karaboga, İhsan, Selim Demirtas, and Turan Karaca. "Investigation of the relationship between the Th17/IL-23 pathway and innate-adaptive immune system in TNBS-induced colitis in rats." Iranian Journal of Basic Medical Sciences 20.8 (2017): 870-879.  WB ;  Rat.  
[IF=3.23] Wang, Xia, et al. "Intermittent food restriction initiated late in life prolongs lifespan and retards the onset of age-related markers in the annual fish Nothobranchius guentheri." Biogerontology 18.3 (2017): 383-396.  WB ;  Fish.  
[IF=3.53] Zhou, Wenjing, et al. "Oxidative stress induced autophagy in cancer associated fibroblast enhances proliferation and metabolism of colorectal cancer cells." Cell Cycle 16.1 (2017): 73-81.  WB ;  
[IF=3.74] Yuan, Zuoqing, et al. "Changes on lipid peroxidation, enzymatic activities and gene expression in planarian (Dugesia japonica) following exposure to perfluorooctanoic acid." Ecotoxicology and Environmental Safety 145 (2017): 564-568.  WB ;  Other Species.  
规格价格50ul/580元购买    100ul/920元购买    200ul/1600元购买    大包装/询价
说 明 书50ul  100ul  200ul
产品类型内参抗体 
研究领域肿瘤  细胞生物  信号转导  细胞骨架  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, Bee, Fish, Guinea Pig, Hamster, Goat, Cat, mt,op
产品应用WB=1:5000-20000 ELISA=1:5000-20000 IHC-P=1:500-1000 Flow-Cyt=1μg/Test (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量42kDa
细胞定位细胞浆 
性    状Lyophilized or Liquid
浓    度1mg/ml
免 疫 原Synthetic MAP peptide derived from human beta-Actin:1-200/375 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
Loading Control
This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 2008].

Function:
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Subunit:
Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Found in a complex with XPO6, Ran, ACTB and PFN1. Component of the MLL5-L complex, at least composed of MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with XPO6 and EMD. Interacts with ERBB2.

Subcellular Location:
Cytoplasm. cytoskeleton.

Tissue Specificity:
Ubiquitously expressed in all eukaryotic cells.

Post-translational modifications:
ISGylated.
Oxidation of Met-44 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. Methionine sulfoxide is produced stereospecifically, but it is not known whether the (S)-S-oxide or the (R)-S-oxide is produced.

DISEASE:
Defects in ACTA1 are the cause of nemaline myopathy type 3 (NEM3) [MIM:161800]. A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-or rod-like structures in muscle fibers on histologic examination. The phenotype at histological level is variable. Some patients present areas devoid of oxidative activity containg (cores) within myofibers. Core lesions are unstructured and poorly circumscribed.
Defects in ACTA1 are a cause of myopathy congenital with excess of thin myofilaments (MPCETM) [MIM:161800]. A congenital muscular disorder characterized at histological level by areas of sarcoplasm devoid of normal myofibrils and mitochondria, and replaced with dense masses of thin filaments. Central cores, rods, ragged red fibers, and necrosis are absent.

Similarity:
Belongs to the actin family.

SWISS:
P60709

Gene ID:
60

Database links:

Entrez Gene: 396526 Chicken

Entrez Gene: 60 Human

Entrez Gene: 11461 Mouse

Entrez Gene: 100009272 Rabbit

Entrez Gene: 81822 Rat

Omim: 102630 Human

SwissProt: P60706 Chicken

SwissProt: P60712 Cow

SwissProt: P60708 Horse

SwissProt: P60709 Human

SwissProt: P60710 Mouse

SwissProt: P29751 Rabbit

SwissProt: P60711 Rat

SwissProt: P60713 Sheep

Unigene: 520640 Human

Unigene: 708120 Human

Unigene: 727576 Human

Unigene: 328431 Mouse

Unigene: 391967 Mouse

Unigene: 94978 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

内参抗体
β-Actin是横纹肌肌纤维中的一种主要蛋白质成分,也是肌肉细丝及细胞骨架微丝的主要成分。具有收缩功能,分布广泛,具有高度保守性,在细胞中的表达相对稳定,因此常被用作校正系统的内参。β-Actin分子量为42 kDa,
此抗体主要用于标记平滑肌及其来源的肿瘤。
我公司开发的β-Actin抗体已被国内外广大科研工作者使用,被称谓:质量信得过产品.
产品图片
Sample:
A549 Cell (Human) Lysate at 30 ug
Primary: Lane1: Anti-beta-Actin (bs-0061R) at 1/500 dilution
Lane2: Anti-beta-Actin (bs-0061R) at 1/1000 dilution
Lane3: Anti-beta-Actin (bs-0061R) at 1/2000 dilution
Lane4: Anti-beta-Actin (bs-0061R) at 1/4000 dilution
Lane5: Anti-beta-Actin (bs-0061R) at 1/5000 dilution
Lane6: Anti-beta-Actin (bs-0061R) at 1/8000 dilution
Lane7: Anti-beta-Actin (bs-0061R) at 1/10000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 42 kD
Observed band size: 47 kD
Sample:
A549 Cell (Human) Lysate at 30 ug
Primary: Lane1: Anti-beta-Actin (bs-0061R) at 1/500 dilution
Lane2: Anti-beta-Actin (bs-0061R) at 1/1000 dilution
Lane3: Anti-beta-Actin (bs-0061R) at 1/2000 dilution
Lane4: Anti-beta-Actin (bs-0061R) at 1/4000 dilution
Lane5: Anti-beta-Actin (bs-0061R) at 1/5000 dilution
Lane6: Anti-beta-Actin (bs-0061R) at 1/8000 dilution
Lane7: Anti-beta-Actin (bs-0061R) at 1/10000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 42 kD
Observed band size: 47 kD
Sample:
Lane1: 293T Cell Lysate at 25 ug
Lane2: A549 Cell Lysate at 25 ug
Lane3: A431 Cell Lysate at 25 ug
Primary: Anti- beta-Actin (bs-0061R) at 1/1000 and 1/5000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 42kD
Observed band size: 42 kD
Sample: Lung lysate at 30ug;
Primary: Anti-beta-actin (bs-0061R) at 1:1000 dilution
Secondary: HRP conjugated Goat-Anti-Rabbit IgG(bse-0295G) at 1:3000 dilution
Predicted band size : 42kD
Observed band size : 42kD
Tissue/cell: human cervical carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-Beta-actin Polyclonal Antibody, Unconjugated(bs-0061R) 1:1500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Blank control: RSC96(blue).
Primary Antibody: Rabbit Anti-beta-Actin /FITC Conjugated antibody (bs-0061R/FITC), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA;
Isotype Control Antibody: Rabbit IgG/FITC(orange) ,used under the same conditions.
Protocol
The cells were fixed with 2% paraformaldehyde (10 min) and then permeabilized with ice-cold 90% methanol for 30 min on ice. The cells were washed twice with 1 X PBS. The cells were incubated in 1 X PBS containing 0.5% BSA + 1 0% goat serum (15 min) to block non-specific protein-protein interactions followed by the incubated with antibody (bs-0061R/FITC, 1μg /1x10^6 cells) for 30 min on ice. Acquisition of 20,000 events was performed.
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